In November 1881 the residents of Musk Creek began agitating for a siding to be provided for their settlement just over halfway between Daylesford and Bullarto, Investigations were made in early 1882 and position selected next to the level crossing. This was on a 1 in 50 grade, a situation avoided if at all possible because sidings cannot be operated safely on such a steep grade. At Musk Creek the solution was to construct the passenger station on the 1 in 50 mainline, with the dead end goods sidings and facilities curving away from the main line to follow horizontal contours around the side of Wheelers Hill.

The station opened in November 1882 with a passenger platform made of sleepers and 3 dead end goods sidings diverging from the main line at the Bullarto end. This resulted in the most unusual situation that inwards traffic to Musk had first to go to Daylesford and be shunted into the sidings at Musk on the return journey towards Bullarto, otherwise the locomotive would be trapped. In 1894 a 10t Fairbanks cart weighbridge was erected in the goods yard

Calls for a more permanent platform resulted in an earth filled, timber faced platform with a ramp at each end being completed in 1889. At this stage a unique one off building was constructed at Musk Creek incorporating the station office/ post office along with a van goods shed. Passenger facilities were in standard portable building and neither had a verandah, which was most unusual.

In 1903 the station master was withdrawn and the station worked under caretaker conditions supervised by Daylesford and in 1905 the name of the station was shorted to Musk as part of move by the Victorian Railways to eradicate multi named stations.

In 1917 No 3 road was removed and in 1941 No 2 road. Also, at this time major changes were made to the passenger facilities with the removal of the portable building, the provision of a separate van goods shed and the conversion of the van goods shed portion of the station building into the waiting room.

In 1962 the remaining goods siding was removed and in 1967 all buildings from the passenger platform and the provision of a mallee shed for passengers the station then became a no one in charge location.

The station as you see it today is as it was when the line closed in 1978.